There we go, Japan become the first Asian team to beat a South American side at a World Cup at the 18th attempt!
It was a contest shaped entirely by the third-minute red card dished out, rightly, to Sanchez.
Kagawa netted the penalty before Quintero's cute free kick pulled the scores level five minutes before half time.
Japan made most of the second half running, though, and were rewarded when Osako headed in the winner with 17 minutes remaining.
That's a huge win in a competitive group, with Senegal facing Poland next.